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Isolation and measurement of betulinic acid

Betulinic acid = 3b-Hydroxy-lup 20(29)-en-28-acid

Betulinic acid = 3b-Hydroxy-lup 20(29)-en-28-acid

Betulinic acid = 3b-Hydroxy-lup 20(29)-en-28-acid

Betulinic acid (BA) is a triterpene carboxylic acid  that induces apoptosis specifically in melanoma cells. BA is a lead  structure for anticancer compounds with direct attack on mitochondria in  tissues of neuroectodermal origin. BC may be obtained by oxidation of  betulin, a natural product from birch bark. Alternatively BA may be  isolated directly from plant tissue.

Bark of a plane tree

Bark of a plane tree

Isolation of betulinic acid from plane bark  (Patent) or from other plant sources yields pure BA that is more easily  to obtain than by oxidation of betulin. Plant tissues are examined for  concentration of betulinic acid, and extraction methods are optimised.  Separation of BA from contaminants originating from plant tissues are  evaluated.

Co-operations:

  • Faculty of Pharmacy of Martin Luther University - PD Dr. Hans-Hermann Rüttinger
  • BioService Halle GmbH, Associate Institute of the Biocenter of Martin  Luther University - Dr. Jutta Kalbitz, PD Dr. Reinhard Paschke

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