Martin Luther University Halle-Wittenberg

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Tomasz Chilczuk

Research Group Pharmacognosy
Institute of Pharmacy
Martin-Luther-University Halle-Wittenberg

Room 704
Hoher Weg 8
D-06120 Halle/Saale

Tel.: +49 345 55 25 115

Academic research

PhD thesis:

Isolation and Characterization of quorum sensing influencing natural products from cyanobacteria

The aim of my project is the isolation and characterization of bioactive compounds from cyanobacteria. My daily work comprises the screening of cyanobacteria for antibacterial activities as well as the influence on the quorum sensing systems of other bacteria. Bioactive compounds are isolated using chromatographic methods such as high performance liquid chromatography (HPLC), flash chromatography and liquid-liquid chromatography. The structure of bioactive compounds is determined by nuclear magnetic resonance spectroscopy (NMR) and high-resolution mass spectrometry (HRMS).

Publications:

  • Chilczuk, T., Monson, R., Schmieder, P., Christov, V., Enke, H., Salmond, G., Niedermeyer, T.H.J. 2020. Ambigols from the Cyanobacterium Fischerella ambigua increase Prodigiosin Production in Serratia spp. ACS Chem Biol, 15: 2929-2936   .
  • Chilczuk, T., Schäberle, T.F., Vahdati, S., Mettal, U., El Omari, M., Enke, H., Wiese, M., König, G.M., Niedermeyer, T.H.J. 2020. Halogenation-guided  chemical screening provides insight into tjipanazole biosynthesis by  the cyanobacterium Fischerella ambigua. ChemBioChem, accepted.
  • Chilczuk, T., Steinborn, C., Breinlinger, S., Zimmermann-Klemd, A.M., Huber, R., Enke, H., Enke, D., Niedermeyer, T.H.J., Gründemann, C. 2020. Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation. Planta Med 2020, 86: 96-103   .
  • Lüddecke, J., Francois, L., Spät, P., Watzer, B., Chilczuk, T., Poschet, G., ... & Forchhammer, K. PII Protein-Derived FRET Sensors for Quantification and Live-Cell Imaging of 2-Oxoglutarate. Sci Rep 2017, 7.

Posters:

  • International VAAM Workshop, Freiburg, 28 – 30.09.2016, “Screening of actinomycetes for inhibition of quorum sensing of C. violaceum CV026 and S. aureus PC322”.
  • First Cyanobacteria Young Investigator Symposium, Rostock, 5 – 9.10.2016, Posterpresentation "Cyanobacterial metabolites with inter-species communication functions".
  • 6th International Conference on Microbial Communication for young scientists, Jena, 20 – 23.03.2017, Posterpresentation "Cyanobacterial metabolites with inter-species communication functions".

Public relations:

  • Niedermeyer, Timo. Chilczuk, Tomasz. Interview mit Katrin Zöfel. Cyanobakterien können Krankheitserreger „verwirren". Deutschlandfunk.de, 28.09.2015.

Teaching at the Institute of Pharmacy:

Supervision of practical courses (practical lab work, seminar)

  • „Mikrobiologie für Pharmazeuten"

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