Martin-Luther-Universität Halle-Wittenberg

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Publikationen der letzten Jahre

Originalarbeiten

2014

Reinhardt N, Fischer J, Coppi R, Blum E, Brandt W, Dräger B. (2014) Substrate flexibility and reaction specificity of tropinone reductase-like short-chain dehydrogenases. Bioorg Chem. 53: 37-49.

2013

A. Junker, J. Fischer, Y. Sichhart, W. Brandt and B. Dräger. 2013. Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase. Frontiers in Plant Science 4:260. doi: 10.3389/fpls.2013.00260.

Jocković, Nebojša; Fischer, Wiebke; Brandsch, Matthias; Brandt, Wolfgang; Dräger, Birgit (2013) Inhibition of Human Intestinal α-Glucosidases by Calystegines, J. Agric. Food Chem., 61 (23), 5550–5557

Sichhart, Yvonne; Draeger, Birgit (2013) Immunolocalisation of spermidine synthase in Solanum tuberosum. Phytochemistry, 91 (2013), 117-121

2012

2011

Aehle, Elke; Mueller, Ulrike; Eklund, Patrik C.;  Willfoer, Stefan M.; Sippl, Wolfgang; Draeger, Birgit (2011)  Lignans as  food constituents with estrogen and antiestrogen activity. Phytochemistry 72 (18), 2396-2405

2010

Nadja Grobe, Marc Lamshöft, Robert G.  Orth,  Birgit Dräger, Toni M.  Kutchan, Meinhart H. Zenk, Michael  Spiteller (2010) Urinary excretion of  morphine and biosynthetic  precursors in  mice.  Proceedings of the National Academy of Sciences U.S.A. 107, 8147-8152.

Kommera, Harish; Kaluđerović, Goran N.; Kalbitz, Jutta; Dräger,  Birgit; Paschke, Reinhard (2010) Small structural changes of pentacyclic  lupane type triterpenoid derivatives lead to significant differences in  their anticancer properties. European Journal of Medicinal Chemistry, 45, 3346-3353.

Kommera, Harish; Kaluđerović, Goran N.; Dittrich, Sebastian; Kalbitz,  Jutta; Dräger, Birgit; Mueller, Thomas; Paschke, Reinhard (2010)  Carbamate derivatives of betulinic acid and betulin with selective  cytotoxic activity. Bioorganic & Medicinal Chemistry Letters 20, 3409-3412.

2009

Biastoff, Stefan; Reinhardt, Nicole; Reva, Veaceslav; Brandt, Wolfgang; Dräger, Birgit (2009) Evolution of putrescine N-methyltransferase from spermidine synthase demanded alterations in substrate binding. FEBS Lett. 583, 3367 - 3374.

Biastoff, Stefan; Brandt, Wolfgang; Dräger, Birgit (2009) Putrescine N-methyltransferase - the start for alkaloids. Phytochemistry 70, 1708-18

2008

Mielke, M.C.; Melzer, E.; Serfling, A.;  Ahmetovic, U.; Horbach,  R.; Reimann, S.; Wohlrab, J.; Dräger, B.;  Deising, H. B. (2008) The molecular basis of adaptation to fungicides in  plant pathogenic Colletotrichum species. In: Modern Fungicides and Antifungal Compounds, Editors H.-W. Dehne et al.

Müller, Ulrike; Mrestani, Yaya; Neubert, Reinhard; Dräger, Birgit  (2008) Chiral separation of the plant lignan matairesinol by capillary  electrophoresis. Electrophoresis 29, 3582 - 2587

Horn, Gert; Kupfer, Astrid; Kalbitz, Jutta; Gerdelbracht, Hans-Jürgen; Kluge, Holger; Eder, Klaus; Dräger, Birgit (2008)  Great  globe thistle - a potential new oil crop.  Eur. J. Lipid Sci. Technol. 110, 662 – 667

Brock, Andrea; Brandt, Wolfgang; Dräger, Birgit (2008) The functional  divergence of short-chain dehydrogenases involved in tropinone reduction. Plant Journal 54, 388 - 401

Freydank, Anna-Carolin; Brandt, Wolfgang; Dräger, Birgit (2008) Protein structure modeling indicates hexahistidine-tag interference with  enzyme activity. Proteins 71, 173 - 183

Kvasnička, František; Jocković, Nebojša; Dräger, Birgit; Ševčík,  Rudolf; Čepl, Jaroslav; Voldřich Michal (2008) Electrophoretic  determination of calystegines A3 and B2 in potato. Journal of Chromatography A 1181, 137–144

2007

Biastoff, S. and Dräger, B. (2007) Calystegines. The Alkaloids, Chemistry and Biology, Volume 64 (Cordell, G.A., eds). New York: Academic Press, 49–102.

Robins, Richard. J.; Molinié, Roland; Kwiecien, Rita A.; Paneth,   Paul; Lebreton, Julien; Bartholomeusz, Trixie Ann; Roscher, Albert;  Dräger, Birgit; Meier, Anna-Carolin; Mesnard, François (2007) Progress  in understanding the N-demethylation of alkaloids by exploiting isotopic techniques. Phytochem. Reviews 6, 51–63

Teuber, Michael.; Meier, Anna-Carolin; Azemi Mohammed Emad; Namyojan, Forough; Wodak, Anja; Brandt, Wolfgang.; Dräger, Birgit (2007) Putrescine N-methyltransferases - A structure-function analysis.  Plant Molecular Biology 63, 787–801

Richter, Ute; Sonnewald, Uwe; Dräger, Birgit (2007) Calystegines in  potatoes with genetically engineered carbohydrate metabolism. Journal of Experimental Botany 58 1603 - 1615

2006

Dräger, Birgit (2006) Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism. Phytochemistry 67, 327–337

Brock, Andrea; Herzfeld, Tobias; Paschke, Reinhard; Koch, Marcus;  Dräger, Birgit (2006) Brassicaceae contain nortropane alkaloids. Phytochemistry 67,  2050-2057

Kaiser, Heike; Richter, Ute; Keiner, Ronald; Brabant, Anja; Hause,  Bettina; Dräger, Birgit (2006) Immunolocalisation of two tropinone  reductases in potato (Solanum tuberosum L.) root, stolon, and tuber sprouts. Planta 225, 127–137

Biastoff, Stefan; Teuber, Michael; Zhou, Zhaohui Sunny;  Dräger, Birgit (2006) Colorimetric activity measurement of a recombinant  putrescine N-methyltransferase from Datura stramonium L. Planta Medica 72, 1136-1141

Stenzel, Olaf; Teuber, Michael; Dräger, Birgit (2006) Putrescine N-methyltransferase in Solanum tuberosum L., a calystegine-forming plant. Planta 223, 200-212

2005

Dräger, B.; Richter, U. (2005) Calystegine und veränderter Kohlenhydratstoffwechsel in Kartoffeln.  BIOforum 28(9), 27-29

Bartholomeusz, Trixie Ann; Bhogal, Remu K; Molinié, Roland; Felpin, François-Xavier; Mathé-Allainmat, Marie; Meier, Anna-Carolin;  Dräger, Birgit; Lebreton, Julien; Roscher, Albert; Robins, Richard. J.;  Mesnard, François (2005) Nicotine demethylation in Nicotiana cell suspension cultures: N’-formylnornicotine is not involved. Phytochemistry 66, 1890-1897

Galgon, Tino; Wohlrab, Wolfgang; Dräger, Birgit (2005) Betulinic acid  induces apoptosis in skin cancer cells and differentiation in normal  human keratinocytes.  Experimental Dermatology 14: 1–9

Boettcher, Chotima.; Fellermeier, Marianne; Boettcher, Christian;   Dräger, Birgit; Zenk, Meinhart H. (2005) How human neuroblastoma cells  make morphine. Proceedings of the National Academy of Sciences U.S.A. 102, 8495–8500

Brock, Andrea; Bieri, Stefan; Christen, Philippe; Dräger, Birgit (2005) Calystegines in wild and cultivated Erythroxylum species. Phytochemistry 66, 1231-1240

Richter, Ute; Rothe, Grit; Fabian, Anne-Kathrin; Rahfeld, Bettina; Dräger, Birgit (2005) Overexpression of tropinone reductases alters  alkaloid composition in Atropa belladonna root cultures.  Journal of Experimental Botany, 56, 645-652

Kaiser, H.; Dräger, B. (2005) Calystegine in Kartoffeln - wo werden sie gebildet? BIOforum 28(3), 34-36


Übersichtsartikel und Buchbeiträge

Aehle, Elke, Dräger, Birgit (2010)  Tropane alkaloid analysis by chromatographic and electrophoretic techniques: An update.  Journal of Chromatography B  878, 1391-1406

Mielke, M. C., Melzer, E., Serfling, A., Ahmetovic, U., Horbach, R.,  Reimann, S., Wohlrab, J., Dräger, B., Deising, H. B. (2008)  The  molecular basis of adaptation to fungicides in plant pathogenic  Colletotrichum species. In: Modern Fungicides and Antifungal Compounds, S. 63-69. DPG-Verlag Editors H.-W. Dehne et al.

Biastoff, Stefan, Dräger, Birgit. (2007) Calystegines. In: The Alkaloids Vol. 64 (Cordell, G. A. ed.) pp. 49 – 102, New York, Academic Press.

Dräger B. (2006)  Biotechnology of Solanaceae Alkaloids: A Model or an Industrial Perspective?   In: Kayser, O. and Quax, W., Medicinal Plant Biotechnology, Vol. 1, Wiley-VCH Weinheim, Germany, pp 237–265.

Dräger, B., Richter, U. (2005) Calystegine und veränderter Kohlenhydratstoffwechsel in Kartoffeln. BIOforum 28(9), 27-29

Kaiser, H., Dräger, B. (2005) Calystegine in Kartoffeln - wo werden sie gebildet? BIOforum 28(3), 34-36

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