Emmanuel Njoya
Arbeitsgruppe Biogene Arzneistoffe
Institut für Pharmazie
Martin-Luther-Universität Halle-Wittenberg
Raum 702
Hoher Weg 8
D-06120 Halle/Saale
Tel.: +49 345 22644
Email: emmanuel.njoya@pharmazie.uni-halle.de
Wissenschaftliche Arbeit
Forschungsthema:
Phytochemische Untersuchungen von Codiaeum-Arten und Isolierung von Substanzen mit Wirkung gegen Entamoeba histolytica aus Codiaeum variegatum
I am interested in the exploration of different plants belonging to the genus Codiaeum which may contain active compounds against Entamoeba histolytica/ Entamoeba dispar as well as other bacterial and fungal pathogens. In my previous research, a bioassay-guided fractionation of the aqueous extract of Codiaeum variegatum resulted in the isolation of the sub-fraction SF9B with significant higher efficacy compared to the unfractionated extract. So, I intend to isolate and characterize individual compounds within SF9B that contribute to the observed biological effects using various chromatographic techniques (e.g. Flash, liquid-liquid, size exclusion or high-performance liquid chromatography). The structures of the isolated compounds will be characterized using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS).
Ausgewählte Publikationen:
- Mfotie Njoya E, Weber C, Hernandez-Cuevas NA, Hon C-C, Janin Y, Melanie F. G. Kamini, Paul F. Moundipa, Nancy Guillén. Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes. PLoS Neglected Tropical Diseases (2014), 8(1): e2607.
- Mfotie Njoya E., Paul F. Moundipa and Helga Stopper. In vitro genotoxic and mutagenic evaluation of the aqueous extract of Codiaeum variegatum and its amoebicidal sub-fraction. Journal of Ethnopharmacology (2014) 155: 823–829.
- Emmanuel Mfotie Njoya, Aristide M. Munvera, Pierre Mkounga, Augustin E. Nkengfack, Lyndy J. McGaw. Phytochemical analysis with free radical scavenging, nitric oxide inhibition and antiproliferative activity of Sarcocephalus pobeguinii extracts. BMC Complementary and Alternative Medicine (2017) 17: 199.
- Emmanuel Mfotie Njoya, Melanie F. G. Kamini, Wilfred A. Abia, Sylvain N. Pechangou, Fréderic N. Njayou, Angèle N. Tchana, and Paul F. Moundipa. Acute and subchronic toxicity evaluation of the aqueous extract of Codiaeum variegatum leaves on Wistar albino rodents of both sexes. Journal of Complementary Medicine Research (2018) 7 (2).
- Emmanuel Mfotie Njoya, Jacobus N. Eloff, Lyndy J. McGaw. Acetone leaf extract of Croton gratissimus selectively inhibits cancer cell proliferation and induces caspase 3/7 activation with additional good antioxidant and anti-inflammatory potential. BMC Complementary and Alternative Medicine (2018) 18 :305. https://doi.org/10.1186/s12906-018-2372-9.
- Jean-Bosco Jouda, Emmanuel Mfotie Njoya, Céline Djama Mbazoa, ZongYuan Zhou, Alain Meli Lannang, Jean Wandji, Yoshihito Shiono, Fei Wang. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways. Bioorganic Chemistry (2018) 80: 216-222.