Martin Luther University Halle-Wittenberg

Further settings

Login for editors

Ronja Kossack

Research Group Pharmacognosy
Institute of Pharmacy
Martin-Luther-University Halle-Wittenberg

Room 702
Hoher Weg 8
D-06120 Halle/Saale

Tel. +49 345 55 25 644

Academic research

PhD thesis:

Isolation and Characterization of antiinfective natural products from Indonesian cyanobacteria strains (ANoBIn project)

My project focuses on the isolation and characterisation of novel natural products from cyanobacteria. During my first year, I sampled interesting habitats in Indonesia like waterbodies, soil or biofilms and successfully isolated about 100 cyanobacteria strains, which now need a lot of attention. Thus my daily work comprises strain maintenance, cultivation, taxonomic characterisation, as well as biological and chemical screening of the strains. Here, the biomass and media extracts of the cyanobacteria strains are tested for antimicrobial, quorum sensing inhibiting and protease inhibiting activity. In case of interesting activities, I try to isolate the responsible compounds e.g. by High Performance Liquid Chromatography (HPLC) and other chromatographic techniques, followed by structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy, tandem High Resolution Mass Spectrometry (HRMS), or other techniques.

Publications:

  • Kossack, R., Breinlinger, S., Nguyen, T.; Moschny, J.; Straetener, J.; Berscheid, A.; Brötz- Oesterhelt, H.; Enke, H.; Schirmeister, T.; Niedermeyer, T.H.J. 2020. Nostotrebin 6 Related Cyclopentenediones and δ-Lactones with  Broad Activity Spectrum Isolated from the Cultivation Medium of the  Cyanobacterium Nostoc sp. CBT1153. J Nat Prod, accepted.   

Posters (selection):

  • 64th Annual Meeting of GA and 9th Joint Natural Product Conference 2016, Copenhagen, “Screening of cyanobacteria extracts against the cysteine protease rhodesain of Trypanosoma brucei”
  • Biology of Bacteria Producing Natural Products; International VAAM-Workshop 2017, Tübingen; “The putative PAINS nostotrebin 6 and derivatives from Nostoc sp. inhibit the trypanosomal cysteine protease rhodesain”

Presentations:

2nd Early Career Researcher Symposium on Cyanobacteria, 2017, Düsseldorf, “The putative PAINS nostotrebin 6 and derivatives from Nostoc sp. inhibit the trypanosomal cysteine protease rhodesain”

Teaching at the Institute of Pharmacy:

Supervision of practical courses (practical lab work, seminar)

  • „Pharmaceutical Biology I“

Up