Martin Luther University Halle-Wittenberg

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Raphael Reher

Research Group Pharmacognosy
Institute of Pharmacy
Martin-Luther-University Halle-Wittenberg

Room 704
Hoher Weg 8
D-06120 Halle/Saale

Tel.: +49 345 55 25 25644

Academic research

Research topic:

Development of novel methods for natural product structure elucidation

Raphael joined the Niedermeyer lab in November of 2020 after completing a first postdoc in the Gerwick lab, UCSD, where Raphael worked on artificial-intelligence assisted MS and NMR methods in order to facilitate and accelerate structure elucidation of novel (marine) natural products with pharmaceutical relevance. In the Niedermeyer lab, Raphael works on establishing high throughput MicroED workflows for subnanomolar Drug Discovery approaches.

Publications:

  • Dührkop K*, Felix-Nothias L*, Fleischauer M, Reher R, Ludwig M, Hoffmann MA, Petras D, Gerwick WH, Rousu J, Dorrestein PC, Böcker S. “Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra” Nat. Biotechnol. 2020 https://doi.org/10.1038/s41587-020-0740-8   .
  • Reher R*, Kim HW*, Zhang C*, Mao HH, Wang M, Nothias LF, Caraballo-Rodriguez AM, Glukhov E, Teke B, Leao T, Alexander KL, Duggan BM, Van Everbroeck EL, Dorrestein PC, Cottrell GW, Gerwick WH. “A Convolutional Neural Network-Based Approach for the Rapid Annotation of Molecularly Diverse Natural Product” J. Am. Chem. Soc. 2020, 142 (9), 4114-4120.
  • Crüsemann M*, Reher R*, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM. “Heterologous expression, biosynthetic studies and ecological function of the selective Gq-signaling inhibitor FR900359.” Angew. Chem. Int. Ed. 2018, 57 (3), 836–840.
  • Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai HF, Müller CE, Kostenis E, König GM, Crüsemann M. "Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359" J. Nat. Prod. 2018, 81 (7), 1628-1635.
  • Reher R*, Kühl T*, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Heimer P, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D., “Deciphering specificity determinants for FR900359-derived Gαq inhibitors based on computational and structure-activity studies” ChemMedChem, 2018, 13 (16), 1634-1643

* equal contribution

Posters:

  • XVI Conference on Marine Natural Products, Peniche, Portugal (08/2019) “Connecting Molecules to Genes and back – The Discovery of a new Swinholide-like Class from a Marine Cyanobacterium
  • DECHEMA conference 28. Irseer Naturstofftage, Irsee, Germany (01/2016) “Structural modifications and biosynthesis of the selective Gq-protein inhibitor FR900359 from Ardisia crenata

Presentations:

  • Oral presentation at ASP2020 Younger Members Virtual Symposium “Improved High Throughput Methods for Natural Products Discovery (08/2020)
  • Invited talk at Gordon Research Conference on Marine Natural Products “SMART 2.0, a Radical New Approach for Determining the Structures of Natural Products (02/2020)
  • Invited talk at the International Association for General and Applied Microbiology (VAAM) Workshop 2017, Tübingen, Germany “FR900359 – an endophyte derived natural product: therapeutic potential, biosynthesis and ecology” (09/2017)

Teaching at the Institute of Pharmacy:

Supervision of practical courses (practical lab work, seminar)

  • „Pharmaceutical Biology III"

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