Martin Luther University Halle-Wittenberg

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Publications

2018

  • Ortlieb, N., Bretzel, K., Kulik, A., Haas, J., Lüdeke, S., Keilhofer, N., Schrey, S. D., Gross, H., Niedermeyer, T.H.J. 2018. Xanthocidin derivatives from the endophytic Streptomyces sp. AcE210 provide insight into the xanthocidin biosynthesis. ChemBioChem, accepted.   
  • Ortlieb, N., Keilhofer, N., Schrey, S.D., Gross, H., Niedermeyer, T.H.J. 2018. Draft Genome Sequence of the Xanthocidin-Producing Strain Streptomyces sp. AcE210, isolated from a root nodule of Alnus glutinosa (L.). Microbiol Resour Announc, 7:e01190-18.   
  • Spohn, M., Edenhart, S., Alanjary, M., Ziemert, N., Wibberg, D., Kalinowski, J., Niedermeyer, T.H.J., Stegmann, E., Wohlleben, W. 2018. Identification of a novel aminopolycarboxylic acid siderophore gene cluster encoding the biosynthesis of ethylenediaminesuccinic acid hydroxyarginine (EDHA). Metallomics, 10: 722-734.   

2017

  • Merdivan, S., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J.,  Schultze N., Steinborn C., Gründemann C., Lindequist, U. 2017. Effects  of extracts and compounds from Tricholoma populinum Lange on degranulation, IL-2 and IL-8 secretion of immune cells. Z Naturforsch C, 72(7-8)c: 277-283.   
  • Merdivan, S., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J.,  Solis M.J., Unterseher, M., Lindequist, U. 2016. Inhibition of degranulation of RBL-2H3 cells by extracts and compounds from Armillaria ostoyae. Planta Med Int Open, 4(1): e1-e7.   

2016

  • Schreuder, H., Liesum, A., Lönze, P., Stump, H., Hoffmann, H.,  Schiell, M., Kurz, M., Toti, L., Bauer, A., Kallus, C., Klemke-Jahn, C.,  Czech, J., Kramer, D., Enke, H., Niedermeyer, T.,  Morrison, V., Kumar, V., Brönstrup, M. 2016. Isolation,  Co-Crystallization and Structure-Based Characterization of  Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin  Activatable Fibrinolysis Inhibitor (TAFIa). Sci Reports, srep32958.   
  • Preisitsch, M., Niedermeyer, T.H.J.,  Heiden, S.E., Neidhardt, I., Kumpfmüller, J., Wurster, M., Harmrolfs,  K., Wiesner, C., Enke, H., Müller, R., Mundt, S. 2016. Cylindrofridins  A–C, Linear Cylindrocyclophane-Related Alkylresorcinols from the  Cyanobacterium Cylindrospermum stagnale. J Nat Prod 79: 106-115.   
  • Preisitsch, M., Heiden, S.E., Beerbaum, M., Niedermeyer, T.H.J., Schneefeld, M., Herrmann, J., Kumpfmüller, J., Thürmer, A., Neidhardt, I., Wiesner, C., Daniel, R., Müller, R., Bange, F.C., Schmieder, P., Schweder, T., Mundt, S. 2016. Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2. marine drugs 14(1): 21.   
  • Iftime, D., Kulik, A., Härtner, T., Rohrer, S., Niedermeyer, T.J.H., Stegmann, E., Weber, T., Wohlleben, W. 2015. Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365. J Ind Microbiol Biotechnol 43: 277-291.   

2015

  • Niedermeyer, T.H.J. 2015. Anti-infective Natural Products from Cyanobacteria. Planta Med 81: 1309-1325.   
  • Bäcker, C., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J., Wurster, M., Bodtke, A.,Lindequist, U. 2015. Taraxastane-Type Triterpene Saponins isolated from Pittosporum angustifolium Lodd. Z Naturforsch B 70: 403-408.   
  • Preisitsch, M., Harmrolfs, K., Pham, H., Heiden, S., Füssel, A., Wiesner, C., Pretsch, A., Swiatecka-Hagenbruch, M., Niedermeyer, T.H.J., Müller, R., Mundt, S. 2015. Anti-MRSA acting Carbamidocyclophanes H − L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. J Antibiot 68: 165-177.   

2014

  • Bäcker, C., Jenett-Siems, K., Siems, K., Wurster, M., Bodtke, A., Niedermeyer, T.H.J., Lindequist, U. 2014. Novel mono- and bisdesmosidic triterpene glycosides from Pittosporum angustifolium Lodd. Z Naturforsch B 69b: 1026–1044.   
  • Niedermeyer, T.H.J.,  Daily, A., Swiatecka-Hagenbruch, M., Moscow, J.A. 2014. Selectivity and  Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing  Cancer Cells. PLoS One 9: e91476.   
  • Niedermeyer, T.H.J., Kurmayer, R., Schmieder, P. 2014. Isolation of microcystins from the cyanobacterium Planktothrix rubescens strain No80. Nat Products Bioprospect 4: 37–45.   

2013

2012

  • Niedermeyer, T.H.J., Strohalm, M. 2012. mMass as a software tool for the annotation of cyclic peptide tandem mass spectra. PLoS One 7: e44913.   

"Publication gap" due to occupation in industry (12/2004 - 10/2013)

2007

  • Niedermeyer, T.H.J., Lalk, M. 2007. Nuclear  amination catalyzed by fungal laccases: Comparison of laccase catalyzed  amination with known chemical routes to aminoquinones. J Mol Catal B Enzym 45: 113–117.   
  • Mikolasch, A., Niedermeyer, T.H.J.,  Lalk, M., Witt, S., Seefeldt, S., Witt, S., Hammer, E., Schauer, F.,  Gesell, M., Ossig, S., Jülich, W.-D., Lindequist, U. 2007. Novel  cephalosporins synthesized by amination of 2,5-dihydroxybenzoic acid  derivatives using fungal laccases. Chem Pharm Bull 55: 412–416.   

2006

  • Mikolasch, A., Niedermeyer, T.H.J., Lalk, M.,  Witt, S., Seefeldt, S., Witt, S., Hammer, E., Schauer, F., Gesell, M.,  Ossig, S., Jülich, W.-D., Lindequist, U. 2007. Novel penicillins  synthesized by biotransformation using laccase from Trametes spec. Chem Pharm Bull 54: 632–638.   
  • Poeckel, D.*, Niedermeyer, T.H.J.*,  Pham, H.T.L., Mikolasch, A., Mundt, S., Lindequist, U., Lalk, M., Werz,  O. 2006. Inhibition of Human 5-Lipoxygenase and Anti-Neoplastic Effects  by 2-Amino-1,4-Benzoquinones. Med Chem 2: 591–595.    (*equal contributions)

2005

  • Niedermeyer, T.H.J., Lindequist, U., Mentel, R., Gördes, D., Schmidt, E., Thurow, K., Lalk, M. 2005. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod 68 : 1728–1731.   
  • Lindequist, U., Niedermeyer, T.H.J., Jülich, W.-D. 2005. The pharmacological potential of mushrooms. Evidence-based Complement Altern Med 2: 285–299.   
  • Niedermeyer, T.H.J.,  Mikolasch, A., Lalk, M. 2005. Nuclear amination catalyzed by fungal  laccases: reaction products of p-hydroquinones and primary aromatic  amines. J Org Chem 70 : 2002–2008.   
  • Manda, K., Hammer, E., Mikolasch, A., Niedermeyer, T.,  Dec, J., Jones, A.D., Benesi, A.J., Schauer, F., Bollag, J.-M. 2005.  Laccase-induced cross-coupling of 4-aminobenzoic acid with  para-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide  and 2,5-dihydroxybenzoic acid methyl ester. J Mol Catal B Enzym 35 : 86–92.    

Book Chapters

  • Niedermeyer, T.H.J. 2016. Annotating and interpreting linear and cyclic peptide tandem mass spectra. In: Nonribosomal Peptide Synthesis: Methods and Protocols, Ed. B. Evans.  Springer. Methods Mol Biol 1401: 1999-   207.   
  • Niedermeyer, T.H.J.,  Kuchmina, E., Wilde, A. 2013. Engineering Cyanobacteria for Industrial  Products. In: Cyanobacteria: An Economic Perspective, Ed. Sharma, N.K.,  Rai, A.K., Stal, L.J. John Wiley & Sons. pp. 303-318.   
  • Niedermeyer, T.,  Brönstrup, M. 2012. Natural-product drug discovery from microalgae. In:  Microalgal Biotechnology: Integration and Economy, Ed. Posten, C.,  Walter, C. de Gruyter. pp. 169–200.    

Total of 28 publications:

first author of 14 publications, second author of 4 publications, senior and/or corresponding author of 10 publications

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Publications in scientific magazines

  • Niedermeyer, T.H.J. 2014. Biologisch aktive Naturstoffe aus Cyanobakterien der Gattung Nostoc. BIOspektrum 20: 151–15. download link   

Patents

  • Niedermeyer, T.H.J., Enke, H., Kramer, D., Moschny, J., Lorenzen,  W., Jahns, S. 2017. Method for Modifying Microcystins and Nodularins. Appl. number  EP17170184.8
  • Niedermeyer, T.H.J., Enke, H., Kramer, D., Moschny, J., Lorenzen, W., Jahns, S. 2017. Modified Microcystins and Nodularins. Appl. number EP17170183.0

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